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You may experience application pauses if you have a large Outlook data file
If you have a large Microsoft Outlook data file in your profile, you may experience application pauses. The larger the data file, the more application pauses you may experience. Note Outlook data files may be either personal folders (.pst) files or...
Fix messages that are stuck in the Outbox - Outlook - Office.com
The usual cause is a large attachment. Click Send/Receive >Work Offline, put the mail in your drafts folder, delete the attachment. Or, read the article for more.