Article ID: 2015895 - View products that this article applies to.
When there are several web applications running under different application pool accounts to ensure security separation you will experience this issue when blob caching is enabled for more than one of the web applications but proper rights are not manually added on the file system path for the blobcache folder. This can cause web applications to become slow or inaccessible.
You will see errors like the following accruing in the event logs:
A runtime exception was detected. Details follow.
An error occured in the blob cache. The exception message was 'Access to the path 'DRIVE:\blobCache\#########2\' is denied.'.
Workarounds in order of easiness:
1. Use a different root blobcache folder for each application.
2. Manually give <LOCALMACHINE>\WSS_WPG full control to DRIVE:\BlobCache.
3. Use the same app pool account for any applications you plan to enable blobcaching on.
Plan for administrative and service accounts (Office SharePoint Server)
(http://go.microsoft.com/fwlink/?LinkId=151500)for other considerations.