Smart cards are not supported in Outlook 2010 when you access your mailbox by using Outlook Anywhere (RPC/HTTP)

Microsoft Outlook 2010 does not support smart card-based credentials when you access your mailbox by using Outlook Anywhere (RPC/HTTP).

To resolve this issue, apply the following update:

Registry key information

Important This section, method, or task contains steps that tell you how to modify the registry. However, serious problems might occur if you modify the registry incorrectly. Therefore, make sure that you follow these steps carefully. For added protection, back up the registry before you modify it. Then, you can restore the registry if a problem occurs. For more information about how to back up and restore the registry, click the following article number to view the article in the Microsoft Knowledge Base: After you install the hotfix package, follow these steps to enable the hotfix:

1. Click Start, click Run, type regedit in the Open box, and then click OK.
2. Locate and then select the following registry subkey:
   HKEY_CURRENT_USER\Software\Microsoft\Office\14.0\Outlook
3. On the Edit menu, point to New, and then click Key.
4. Type RPC, and then press ENTER.
5. Locate and then select the following registry subkey:
   HKEY_CURRENT_USER\Software\Microsoft\Office\14.0\Outlook\RPC
6. On the Edit menu, point to New, and then click DWORD (32-bit) value.
7. Type EnableSmartCard, and then press ENTER.
8. Right-click EnableSmartCard, and then click Modify.
9. In the Value data box, type 1, and then click OK.
10. Exit Registry Editor.
    

Microsoft has confirmed that this is a problem in the Microsoft products that are listed in the "Applies to" section.