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"Exception has been thrown by the target" error in a hybrid deployment of Office 365 and your on-premises environment
Article ID: 2626696 - View products that this article applies to.
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In a hybrid deployment of Microsoft Exchange Online in Microsoft Office 365 and an on-premises Microsoft Exchange Server 2010 environment, you experience one of the following symptoms:
This issue occurs if the Internet Information Services (IIS) configuration is missing the svc-Integrated handler mapping. The following screen shot shows an example of the svc-Integrated handler mapping in IIS:
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Note Before you follow these steps, back up your IIS configuration.
To resolve this issue, run the ServiceModelReg.exe –r command to reinstall the handler mappings in IIS. To do this, follow these steps:
When you experience this issue, you may notice that other connections to the Client Access Server (CAS), such as the connection for configuring user profiles through the Autodiscover service, aren't affected. This is because this operation doesn't use the svc endpoint. Any connection that uses the svc endpoint won't work. Other endpoints probably will not be affected.
For more information, see the following Office 365 Community article:
Hybrid mailbox move throws error "Exception has been thrown by the target of an invocation."
Still need help? Go to the Office 365 Community
Article ID: 2626696 - Last Review: May 15, 2013 - Revision: 15.0