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The Microsoft Exchange Information Store (MSExchangeIS) service occasionally stops responding, and the following Event ID 1002 entry is logged: 

Unhandled exception (System.NullReferenceException: Object reference not set to an instance of an object.

   at Microsoft.Exchange.Server.Storage.LogicalDataModel.SearchFolder.BaseViewOperatorDefinition(Context context, Mailbox mailbox, IList`1 columnsToFetch, SearchCriteria criteria, Nullable`1 associated)

   at Microsoft.Exchange.Server.Storage.LogicalDataModel.SearchFolder.<DoSearchPopulation>d__210.MoveNext()

   at Microsoft.Exchange.Protocols.MAPI.MapiViewMessage.<CreateMaterializedRestrictionAndPopulate>d__138.MoveNext()

   at Microsoft.Exchange.Server.Storage.MapiDisp.MailboxTaskQueue.RunTaskStep(MailboxTaskContext mailboxTaskContext, QueueItem


The MSExchangeIS process stops responding because of an unhandled System.NullReferenceExceptions exception that's generated multiple times per day.


To fix this issue, install the following cumulative update: 

Cumulative Update 14 for Exchange Server 2019 or a later cumulative update for Exchange Server 2019

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