Assume that you have a database that has Query Store enabled in Microsoft SQL Server 2016. When the database is under heavy workloads, spinlock contention may occur and server performance may become slow. In particular, you may see heavy contention on the QUERY_STORE_ASYNC_PERSIST spinlock or SPL_QUERY_STORE_STATS_COOKIE_CACHE spinlock.
To work around this issue, switch Query Store to read-only mode or disable Query Store on the database.
Microsoft has confirmed that this is a problem in the Microsoft products that are listed in the "Applies to" section.