Certain add-ins may cause compatibility issues with Office applications. If your Office application successfully started in Safe Mode, you'll want to disable the application add-ins and COM add-ins one at a time:
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With the Office application still in Safe Mode, select File > Options > Add-Ins
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At the bottom of the window, check the Manage drop-down list for Add-ins options, such as Word Add-ins or Excel Add-ins, and then choose Go. If you can't find an Add-ins option specific to the Office app in the Manage list, choose COM Add-ins, and then select Go.
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When the COM Add-ins window opens, select one of the checkboxes to clear it, and then choose OK.
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Select File > Exit and restart Outlook (not in Safe Mode this time).
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If your Office app starts, there's a problem with the add-in you unchecked. We recommend you visit the company website for the add-in to check for an updated version you can install. If there isn't a newer version or if you don't need to use the add-in, you can leave it unchecked or remove it from your PC
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If your Office app doesn't start, repeat the steps to clear the checkbox for the other add-ins one-by-one. If all add-ins are unchecked and you still can't open your Office application, the problem isn't related to add-ins.
