A hotfix is available for Microsoft BizTalk Server to add design time support to Microsoft .NET Framework 4.5.2 for BizTalk projects. This hotfix enhances BizTalk Server so that it can accommodate the .NET Framework roadmap with the intent of supporting version 4.5.2 going forward.
Cumulative update information
The fix to add design time support is included in Cumulative Update 2 for BizTalk Server 2013 R2.
Learn about the service pack and cumulative update list for BizTalk Server.
Learn about BizTalk Server hotfixes and cumulative update support.