When you use memory-optimized tables in Microsoft SQL Server 2016, it takes a long time to create or update statistics on a large memory-optimized table that has a columnstore index. Similarly, it might take a very long time to compile a query on the table if the automatic update statistics option AUTO_UPDATE_STATISTICS is turned on.
Cumulative Update information
This update was first introduced in the following cumulative update of SQL Server.
Each new cumulative update for SQL Server contains all the hotfixes and all the security fixes that were included with the previous cumulative update. We recommend that you download and install the latest cumulative updates for SQL Server:
Microsoft has confirmed that this is a problem in the Microsoft products that are listed in the "Applies to" section.