This can occur if Windows Installer Logging is enabled, but the Windows Installer engine cannot properly write the uninstallation log file. This condition can occur if the Windows Installer's application heap becomes freed and thus loses the information on where to store the log file. When this occurs, Windows Installer attempts to write to the location 'C:\Windows\System32' and addresses it as a file. Proper behavior would be to write to the following location and file name: 'C:\Users\<username>\AppData\Local\Temp\MSIxxxxxx.log'.
Microsoft has confirmed this to be a problem in the operating systems listed in the Applies To section of this article.
To work around this issue, stop and restart the Explorer.exe process using Task Manager.