You might have been redirected to this Microsoft Knowledge Base article from the following IIS error message:
To help resolve this error, use the Metabase Explorer tool to modify the metabase permissions. For more information about the Metabase Explorer tool and the IIS 6.0 resource Kit Tools, please see:
The IIS 6.0 Resource Kit Tools
Note If you are using ASP.Net 2.0 and you must grant metabase permissions to a Windows user account, run the ASP.NET IIS Registration Tool command together with the -ga option. For example, the following command grants the Windows user account <WindowsUserAccount> permissions to the IIS metabase:
Note Always back up the metabase before you edit it.
IIS Metabase (IIS 6.0)