MPIO is not supported for pass-through disks in virtual machines
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Applies to: Windows 10, version 1809Windows Server 2019, all versionsWindows 10, version 1803Windows Server version 1803Windows Server Standard CoreWindows 10, version 1709Windows Server 2016 DatacenterWindows Server 2016 StandardWindows Server 2012 R2 DatacenterWindows Server 2012 R2 StandardWindows Server 2012 DatacenterWindows Server 2012 StandardWindows Server 2008 R2 DatacenterWindows Server 2008 R2 StandardMore
Microsoft Multipath I/O (MPIO) is not supported on either the Hyper-V guest or the Hyper-V host for disks that are exposed as a pass-through to a virtual machine. However, MPIO is supported for disks that are exposed through iSCSI or virtual fiber channel (FC) to a virtual machine. You should not try to multipath disks that share the same hardware ID (combination of vendor ID and product ID) and are concurrently exposed through supported (iSCSI or virtual FC) and unsupported (pass-through) means.
If you try to configure MPIO for disks that are exposed as a pass-through to a virtual machine, this may interfere with the ability to multipath disks that share the same hardware ID but are exposed through supported means (iSCSI or virtual FC).
Additionally, using MPIO on the Hyper-V host may cause Offload Data Transfer (ODX) requests from the client to fail.
Such a configuration is neither recommended nor supported.