In a Microsoft Exchange Server 2013 or Exchange Server 2016 environment, SharePoint discovery administrators are using eDiscovery to search Exchange mailboxes. After the search is completed, the following URL link is provided to allow access for the search result:
https://mysite.domain.com/OWA/integrated/?viewmodel=ItemReadingPaneViewModelPopOutFactory&IsDiscoveryView=1&exsvurl=1&ItemID=ItemIDHowever, if the Exchange server being accessed is in a different site than where the mailbox server that hosts the data is, you will receive an HTTP 500 error.
This issue occurs because the http access path isn't interpreted correctly.
For Exchange Server 2013To fix this issue, install Cumulative Update 14 for Exchange Server 2013 or a later cumulative update for Exchange Server 2013.
For Exchange Server 2016To fix this issue, install Cumulative Update 3 for Exchange Server 2016 or a later cumulative update for Exchange Server 2016.
Microsoft has confirmed that this is a problem in the Microsoft products that are listed in the "Applies to" section.