Assume that you configure Enterprise Mode by using an Enterprise site list XML file on a local computer. When you use Microsoft Edge on Windows 10, Edge does not read the Enterprise Mode site list.
This issue occurs because Edge is a universal Windows App, and it cannot access the UNC location.
We recommend that you use the "http" path for the site list XML file.
Instead of using a UNC file path, you can use the file:// location on a local computer, and then add the “all application packages” ACL to the specific local file. Then, set read and execute permissions.