Microsoft SQL Server 2016 Service Pack 2 (SP2) is added to the list of supported platforms for Microsoft BizTalk Server 2016 starting in Cumulative Update 5 (CU5).
Microsoft has confirmed that this is a problem in the Microsoft products that are listed in the "Applies to" section.
For information about the service packs and cumulative update list for BizTalk Server, see the following article in the Microsoft Knowledge Base:
2555976 Service pack and cumulative update list for BizTalk Server
For more information about BizTalk Server hotfixes, see the following article in the Microsoft Knowledge Base:
2003907 Information about BizTalk hotfixes and Service Pack support