Outlook.exe is typically located in one of the following folders, depending on the version of Outlook that you are running:
C:\Program Files\Microsoft Office\Office14
C:\Program Files\Microsoft Office\Office12
C:\Program Files\Microsoft Office\Office 11
C:\Program Files\Microsoft Office\Office 10
C:\Program Files\Microsoft Office\Office 9
Right-click Outlook.exe, and then click Properties.
On the Compatibility tab, click to clear the Run this program in compatibility mode for check box.
Try to start Outlook.
Did this fix the problem?
Check whether the problem is fixed. If the problem is fixed, you are finished with this section. If the problem is not fixed, you can contact support.
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For more information about how to create profiles in Outlook, click the following article numbers to view the articles in the Microsoft Knowledge Base:
195718 How to create a new e-mail profile in Outlook 2000
195723 How to create a new personal folder (.pst) file for an Internet Mail Only (IMO) e-mail account in Outlook 2000
For more information about Windows Program Compatibility mode, click the following article number to view the article in the Microsoft Knowledge Base:
292533 How to use Windows Program Compatibility mode in Windows XP
This issue may occur on a computer that is running Windows XP if the Outlook.exe file was configured to open by using the Windows Program Compatibility mode setting. When you set compatibility for Outlook to Windows 95 or to Windows 98/Windows Millennium Edition, Outlook displays this error message. This occurs because the location of the Outlook Profile information in the registry is different on a Windows XP-based computer than it is on a computer that is running Windows 95, Windows 98, or Windows Millennium Edition.
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Microsoft Outlook 2010, Microsoft Outlook 2010 with Business Contact Manager, Microsoft Office Outlook 2007, Microsoft Office Outlook 2007 with Business Contact Manager, Microsoft Office Outlook 2003, Microsoft Office Outlook 2003 with Business Contact Manager, Microsoft Outlook 2002 Standard Edition, Microsoft Outlook 2000 Standard Edition