You have a Microsoft Application Virtualization (App-V) virtual application package version 220.127.116.115 on a client computer that is running Windows 7 or Windows Server 2008 R2. When you try to run the virtual application, the application does not run and is not inventoried by Microsoft System Center 2012 Configuration Manager.
This problem occurs because an App-V version 18.104.22.1685 virtual application is not supported on Windows 7 or on Windows Server 2008 R2.
To resolve this problem, install App-V 4.6 Service Pack 1 (SP1) or a later version. Then, install hotfix 2645225.
For more information about hotfix 2645225, click the following article number to view the article in the Microsoft Knowledge Base:
2645225 Hotfix Package 5 for Microsoft Application Virtualization 4.6 SP1: December 2011
For more information about how to use System Center 2012 Configuration Manager to install and manage virtual applications as deployment types in an application, visit the following Microsoft TechNet website:
Microsoft System Center 2012 Configuration Manager, Windows 7 Professional, Windows 7 Enterprise, Windows 7 Home Basic, Windows 7 Home Premium, Windows 7 Ultimate, Microsoft Application Virtualization 4.5 for Windows Desktops, Microsoft Application Virtualization 4.5 for Terminal Services