When the App-V 5.0 Management console is installed on a drive other than the C: drive, launching the console may fail and generate the following error message:
HTTP Error 500.19 - Internal Server Error Module IIS Web Core Notification Unknown Handler Not yet determined Error Code 0x80070005 Config Error Cannot read configuration file due to insufficient permissions Config File \\?\E:\Program Files\Microsoft Application Virtualization Server\ManagementService\web.config
This occurs due to invalid NTFS permissions on the drive hosting the App-V 5.0 Management Service INSTALLDIR directory.
To resolve this issue, give the local computers Users group Read & execute, List folder contents and Read permissions to the root of the drive the hosts the App-V Management consoles INSTALLDIR directory. The INSTALLDIR parameter can be found referencing the following registry key:
App-V 5.0 Console HTTP Error 500.19 - Internal Server Error Error Code 0x80070005 Config Error Cannot read configuration file due to insufficient permissions