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All Exchange features are disabled on Active Directory Users and Computers when you try to change some attributes.
When you try to change some exchange attributes in Active Directory Uses and Computers, you receive all Exchange tabs on disabled state and you can't change any of their values.
This error may occur because the user attribute homeMDB is value was set as <not set>.
There are two ways to resolve the problem, follow both methods:
Method 1: Change value of homeMDB attribute of affected user
Open ADSIEdit.msc ADSIEdit.msc is avaiable in support tools found in the support subdirectory on the Operation System cd.
In the Domain section, expand your domain
Find the affected user and right click on it
Select the homeMDB attribute and click Edit
Fill out the text box with a valid path, like CN=<Mailbox Store (Server)>,CN=First Storage Group,CN=InformationStore,CN=<Server>,CN=Servers,CN=<First Administrative Group>,CN=Administrative Groups,CN=<Organization>,CN=Microsoft Exchange,CN=Services,CN=Configuration,DC=<domain>,DC=<com>
Method 2: Reconnect mailbox
Open Active Directory Users and Computers, right click on affected user then click Exchange Tasks…
Mark Remove Exchange Attributes and click Next, Next and Finish
Open Exchange System Manager
Expand Administrative Groups
Expand <Administrative Group>
Expand <Storage Group>
Expand <Mailbox Store>
Right click on Mailboxes and click Run Cleanup Agent
On the right frame, right click on the affected user and then click Reconnect and associate again to the user used in step 1