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You cannot configure the filter settings in Microsoft Forefront Security for SharePoint.
This issue occurs when the AntigenPMDLL.dll file does not close its handle on the Scanjobs.fdb file in a timely manner.
To resolve this issue, install Forefront Security for SharePoint with Service Pack 3 (SP3). For more information, click the following article number to view the article in the Microsoft Knowledge Base:
967995 Description of Forefront Security for SharePoint with Service Pack 3
Microsoft has confirmed that this is a problem in the Microsoft products that are listed in the "Applies to" section.