If you prefer to skip the video and go straight to written instructions, see Send automatic out of office replies from Outlook.
Create an automatic reply
Click FILE > Automatic Replies > Send Automatic Replies.
Add and format your message.
Optionally, click Only send during this time range, and then pick start and end dates.
For people outside your org
Click the Outside My Organizationtab, and then click Auto-reply to people outside my organization.
Add and format the message for this group.
To turn on your automatic 'Out of Office' reply in Outlook 2016, click FILE, then click Automatic Replies.
You can do the same thing in Outlook 2010 or Outlook 2013.
In the web version of Outlook, click the gear icon, then Automatic Replies.
If you don't see the Automatic Replies button, you might need some extra help to get started.
Go to aka.ms/autoreply to learn more.
In the Automatic Replies window, select Send automatic replies.
Decide when you want your reply to turn on and off.
Enter your custom reply message.
And, you can even create a different message for people outside your organization.
Click OK, and you are done.
For more on setting up and customizing your 'Out of Office' reply, go to aka.ms/autoreply.