If the popup blocker is not working after enabling, try these solutions:
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Make sure Microsoft Edge is up to date: Select Settings and more  > Settings > About Microsoft Edge. If there is an update available, you can apply it from here.
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Scan your device for malware: For more information, see Stay protected with Windows Security.
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Disable your extensions: See if an extension is getting in the way. Select Settings and more  > Extensions, then select the switch to the right of each extension to disable it. If popups are being blocked after this, re-enable them one at a time to determine which one is causing the issue.
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Block third-party cookies: To do this, select Settings and more  > Settings > Site permissions > Cookies and site data. Then, ensure Block third-party cookies is set to On.
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Clear your browser cache: For more, see View and delete browser history in Microsoft Edge.
Note: This topic is for the new Microsoft Edge. Get help for the legacy version of Microsoft Edge.