There's more than one way to set up a PC to make it more accessible, depending on your needs. Everybody works differently, and there are lots of settings you can change so you can use your PC the way you want.
The most commonly used accessibility options are available in PC settings. To get to them, swipe in from the right edge of the screen and tap Settings (or if you're using a mouse, point to the lower-right corner of the screen, move the mouse pointer up, and click Settings), tap or click Change PC settings, and then tap or click Ease of Access.
Common accessibility options are also available from the sign-in screen. Click the Ease of Access button
You can also get to accessibility settings from the desktop. To do this, press the Windows logo key + U.
For more info about other assistive technologies, go to the Microsoft Accessibility website.