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This article lists the known issue that you may experience after you install the Microsoft .NET Framework 4.6.2. 

Product issues for the .NET Framework 4.6.2

For information about the issue that you may experience after you install the .NET Framework 4.6.2 and its workaround, see the following Microsoft Knowledge Base article. 

Description

Path.GetDirectoryName and Path.GetPathRoot do not work with URIs when you target the .NET Framework 4.6.2

.NET 4.6.2. Framework client driver for Always Encrypted resulting in intermittent failures to decrypt individual rows

Applications that rely on TLS 1.2 strong encryption experience connectivity failures after a Windows upgrade

References

For more information about application compatibility in the .NET Framework 4.6.2, see Application compatibility in the .NET Framework 4.6.2.

For the known issues in earlier versions of the .NET Framework, see the following Knowledge Base articles:
 

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