Consider the following scenario:
You have BizTalk Server 2009 Cumulative Update 6 (CU6) installed on Microsoft BizTalk Server 2009 or you use Microsoft BizTalk Server 2010.
You use Microsoft System Center Operations Manager to monitor the BizTalk applications, or run any other application that makes BizTalk WMI calls on this computer.
In this scenario, applications that are running on the computer may stop responding, or crash periodically.
This issue occurs because of deadlocks.
Cumulative update information
This issue was first fixed in the following cumulative update of BizTalk Server 2010:
To work around the issue, restart the server periodically.
Microsoft has confirmed that this is a problem in the Microsoft products that are listed in the "Applies to" section.
For more information about BizTalk Server hotfixes, see Information about BizTalk Server hotfixes.