Consider the following scenario:
Assume that you have an orchestration with a two-way receive port and a Simple Object Access Protocol (SOAP) Receive Location (RL) in Microsoft BizTalk Server.
You use the Specify now port binding in the Port Configuration Wizard in which you can specify the pipelines and address at design time.
After you install the Cumulative Update 6 for BizTalk Server 2013 R2, you may notice that the BizTalk application deployment with Specify now port binding fails.
This issue is fixed in the following cumulative update for BizTalk Server:
Microsoft has confirmed that this is a problem in the Microsoft products that are listed in the "Applies to" section.
For information about the service packs and cumulative update list for BizTalk Server, click the following article number to view the article in the Microsoft Knowledge Base:
2555976 Service pack and cumulative update list for BizTalk Server
For more information about BizTalk Server hotfixes, click the following article number to view the article in the Microsoft Knowledge Base:
2003907 Information about BizTalk hotfixes and Service Pack support