After you have installed Feature Pack 2 (FP2) Cumulative Update 3 (CU3), FP2 CU4 or FP3 CU5 on Microsoft BizTalk Server 2016, you try to open or create a BizTalk project in Microsoft Visual Studio. In this situation, you will get an error message due to the unsigned Assembly BizTalkApplication.dll in BizTalkApplication.vsix:
The 'PublishCommandPackage' package did not load correctly.
Microsoft has confirmed that this is a problem in the Microsoft products that are listed in the "Applies to" section.
This problem is fixed in the following cumulative update for BizTalk Server:
Cumulative Update 6 for BizTalk Server 2016
For information about the service packs and cumulative update list for BizTalk Server, see the following article in the Microsoft Knowledge Base:
2555976 Service Pack and cumulative update list for BizTalk Server
For more information about BizTalk Server hotfixes, see the following article in the Microsoft Knowledge Base:
2003907 Information about BizTalk hotfixes and Cumulative Update support