Symptoms
When you try to install a cumulative update to a BizTalk Server, the installation is unsuccessful, and you receive the following exception:
Faulting application name: BtsDeploySystemAssemblyTask.exe
Exception code: 0xe0434352Cause
This issue occurs when one of the following conditions is true:
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You apply the cumulative update on a server that has only the MQSAgent role installed.
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You apply the cumulative update on a server that has BizTalk Server installed but not configured.
Resolution
Cumulative update information
For BizTalk Server 2013 R2
The fix that resolves this issue is included in Cumulative Update 3 for BizTalk Server 2013 R2.
Status
Microsoft has confirmed that this is a problem in the Microsoft products that are listed in the "Applies to" section.
References
Learn about service pack and cumulative update list for BizTalk Server. Learn about BizTalk Server hotfixes and cumulative update support.