Microsoft Mouse and Keyboard Center software provides default commands for all of the mouse buttons. You can reassign some buttons to different commands or keyboard shortcuts to better fit your work style. You can also disable buttons you might press accidentally, such as the wheel button. If you don't have the software or want to learn more, go to Mouse & Keyboard Center Download

To reassign a button across all applications

  1. Using the mouse that you want to configure, start Microsoft Mouse and Keyboard Center.

  2. Select basic settings.

  3. Select the button that you want to reassign.

  4. In the list of the button that you want to reassign, select a command.
    To disable a button, select Disable this button.


  • You must assign the Click command to either the left or right button. You can assign this command to additional buttons if you want.

  • Reassigned button commands may not work as expected for some programs or games. Some programs or games may not support customized button assignments.

  • Some mouse models include specialized buttons that cannot be reassigned.

How do I reassign my mouse buttons for a specific application?

You can assign mouse buttons to perform different commands in different programs. For example, you can assign the same mouse button to activate Digital Ink when in PowerPoint, a macro when in a game, and the Magnifier when in any other application. 

To reassign a button for a specific program

  1. Using the mouse that you want to configure, start Microsoft Mouse and Keyboard Center.

  2. Select the app-specific settings.

  3. Click Add New button, select the program that you want.
    If the program that you want is not on the list, click Manually Add a Program at the bottom, select the program.

  4. In the button command list, select a command.

To use a button that has been reassigned for a specific program

  • Start the program and click the reassigned button.

Note: If you open a program by using the Run as administrator command, you will not have access to application-specific mouse button settings. Instead, the mouse will use the global mouse button assignments. To enable application-specific mouse button settings, open the application without administrator credentials, or log on to Windows as an administrator.

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