MQSeries send ports fail and return MQ reason code 2082 when they send messages to an alias queue that points to a remote clustered queue manager.
Note This issue was introduced in Cumulative Update 7 for BizTalk Server 2016.
Microsoft has confirmed that this is a problem in the Microsoft products that are listed in the "Applies to" section.
This problem is fixed in the following cumulative update for BizTalk Server:
Cumulative Update 9 for BizTalk Server 2016
For information about the service packs and cumulative update list for BizTalk Server, see the following article in the Microsoft Knowledge Base:
2555976 Service pack and cumulative update list for BizTalk Server
For more information about BizTalk Server hotfixes, see the following article in the Microsoft Knowledge Base:
2003907 Information about BizTalk hotfixes and Cumulative Update support