There are some situations in which non-Microsoft security, encryption, or backup software may be causing Office to crash or display upload failed errors.
Why is this happening?
A few reasons why this can occur are:
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The non-Microsoft software has a file momentarily locked at the time when Office needs to use the file.
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The non-Microsoft software is using an unusual amount of network bandwidth at the same time that Office or OneDrive are trying to transfer data, leading to upload failures.
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The non-Microsoft software intercepts and/or alters network operations from Office or OneDrive, leading to data corruption.
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The non-Microsoft software intercepts Office writes to the disk and modifies the data in unexpected ways.
What can I do about it?
We recommend checking to see if the Office Document Cache folder (%LOCALAPPDATA%\Microsoft\Office\16.0\OfficeFileCache) can be excluded from non-Microsoft software jobs.
Important: Make sure the exclusion you add also includes any subfolders of the Office Document Cache folder.
If you can't exclude those folders, or if that doesn't solve the problem, consider uninstalling that non-Microsoft software.