Symptoms
In Microsoft Exchange Server 2019 or Exchange Server 2016, consider the following scenario:
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User A sends an email message to User B.
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User B composes a reply by adding a S/MIME (Secure/Multipurpose Internet Mail Extensions) signature.
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User B saves the reply as a draft.
In this scenario, you find that the draft of the reply does not have a value for the InReplyTo property.
Resolution
To fix this issue, install one of the following updates:
For Exchange Server 2019, install the Cumulative Update 3 for Exchange Server 2019 or a later cumulative update for Exchange Server 2019.
For Exchange Server 2016, install the Cumulative Update 14 for Exchange Server 2016 or a later cumulative update for Exchange Server 2016.
References
Learn about the terminology that Microsoft uses to describe software updates.