If you use roaming profiles that enable the option to delete profiles after you log off, Enterprise Mode for Internet Explorer 11 is no longer active after you log off from the computer.
This issue occurs because the local profiles are cleared up when you log off, and then the cached copy of the Enterprise Mode Internet Explorer (EMIE) website lists cannot be used. However, the CurrentVersion registry entry is still available under the HKEY_CURRENT_USER\Software\Microsoft\Internet Explorer\Main\EnterpriseMode registry key. Therefore, Internet Explorer does not download the website list again.
To resolve this issue, install the most recent cumulative security update for Internet Explorer. To do this, go to Microsoft Update. Additionally, see the technical information about the most recent cumulative security update for Internet Explorer.
This update was first included the March cumulative security update for Internet Explorer (MS15-018).
Microsoft has confirmed that this is a problem in the Microsoft products that are listed in the "Applies to" section.
See the terminology that Microsoft uses to describe software updates.