Symptoms
After you update BizTalk Server, the BizTalk Server Adapter for MQSeries writes thousands of event log entries when no MQSeries queue exists.
Resolution
The fix that resolves this issue is included in the following updates for BizTalk Server:
Cumulative Update 5 for BizTalk Server 2016
Cumulative Update 8 for BizTalk Server 2013 R2
Status
Microsoft has confirmed that this is a problem in the Microsoft products that are listed in the "Applies to" section.
References
Service pack and cumulative update list for BizTalk Server
Information about BizTalk Server hotfixes and cumulative update support