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You cannot create an AD DS synchronization connection that has multiple domains selected after you install the Cumulative Update in either KB 2459257 or KB 2459258
Article ID: 2490381 - View products that this article applies to.
Consider the following scenario. You install either the Cumulative Update in KB 2459257 or the Cumulative Update in KB 2459258 on a SharePoint 2010 server. Then, you try to create an Active Directory Domain Services (AD DS) synchronization connection that has multiple AD DS domains selected. In this scenario, you receive the following error message:
Unable to process Create message
To create an AD DS synchronization connection that has multiple domains selected, follow these steps:
Microsoft has confirmed that this is a problem in the Microsoft products that are listed in the "Applies to" section.