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This article lists the known issues that you may experience after you install the Microsoft .NET Framework 4.6. 

Product issues for the .NET Framework 4.6

For more information about issues that you may experience after you install the .NET Framework 4.6 and about the available workarounds, see the following Microsoft Knowledge Base articles. 

Article ID

Description

3045727

You cannot install WSUS 3.2 on a computer that has the .NET Framework 4.6 installed

3065367

RyuJIT settings cause managed applications to crash after you install Microsoft .NET Framework 4.6

3069491

Category names in a property grid cannot be read in the Visual Studio after you install the .NET Framework 4.6

3069494

Cannot connect to a server by using the ServicePointManager or SslStream APIs after upgrade to the .NET Framework 4.6

3069495

Changes in the ToString() method in the ContentDispositionHeaderValue class in the .NET Framework 4.6

3074856

The token returned from System.Web.HttpRequest.TlsTokenBindingInfo is incorrect when you use the .NET Framework 4.6

3076436

Performance issue when you uses WCF to send XML SOAP messages in the .NET Framework 4.6

3078663

Add Connection dialog box doesn't load server names in the drop-down list after you apply the .NET Framework 4.6

3079225

Unicode characters do not render correctly in a WPF application in Windows 10

3118750

Known issue for security updates 3098779 and 3097997 for the .NET Framework 4.5.1 and 4.5.2 after you install the .NET Framework 4.6 on Windows 8.1, Windows RT 8.1, and Windows Server 2012 R2

3087184

SharePoint 2013 Setup error if the .NET Framework 4.6 is installed

4458166

Applications that rely on TLS 1.2 strong encryption experience connectivity failures after a Windows upgrade

References

For more information about application compatibility in the .NET Framework 4.6, see Application Compatibility in the .NET Framework 4.6.

Check out known issues that you may experience after you install Microsoft .NET Framework 4.5.2.

Check out known issues that you may experience after you install Microsoft .NET Framework 4.5.1.

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