Assume that on Windows Server that hosts Microsoft Exchange Server 2016 or Exchange Server 2013, the disk drives that host the operating system and databases are formatted with different sector sizes. In this situation, Exchange indicates that search indexes are corrupted and repeatedly fail over databases to another server.
This issue occurs because the sector size on the system disk does not match that on the database disk. The Exchange search process experiences IO exceptions which cause a failover event.
For Exchange Server 2013
For Exchange Server 2016
After the appropriate Cumulative Update is applied, Exchange Search will function correctly regardless of the sector size that's used on all attached drives.
Microsoft has confirmed that this is a problem in the Microsoft products that are listed in the "Applies to" section.