After you update BizTalk Server, the BizTalk Server Adapter for MQSeries writes thousands of event log entries when no MQSeries queue exists.
The fix that resolves this issue is included in the following updates for BizTalk Server:
Cumulative Update 5 for BizTalk Server 2016
Cumulative Update 8 for BizTalk Server 2013 R2
Microsoft has confirmed that this is a problem in the Microsoft products that are listed in the "Applies to" section.