Symptoms
After a network disruption, you may receive the following error message:
The HTTP send adapter cannot complete the transmission within the specified time.
In this situation, HTTP send ports may stall until the service is restarted.
Resolution
The fix that resolves this issue is included in the following updates for BizTalk Server
Cumulative Update 5 for BizTalk Server 2016
Cumulative Update 8 for BizTalk Server 2013 R2
Status
Microsoft has confirmed that this is a problem in the Microsoft products that are listed in the "Applies to" section.
References
Service pack and cumulative update list for BizTalk Server
Information about BizTalk Server hotfixes and cumulative update support